In Call of Duty: Black Ops 6, safes are hidden in each campaign mission and contain valuable cash and blueprints. To unlock them, players must find and solve a unique puzzle—often involving radios, blacklights, or other interactive clues to reveal access codes. Missions such as "Blood Feud" and "Hunting Season" require players to track signals and tune radios to unlock safes. Completing these puzzles rewards players with in-game currency, enhancing gameplay options. For full details on each safe location and solution.